Publications

Click here for articles in press and recent preprints

A Novel Macrophage Subpopulation Conveys Increased Genetic Risk of Coronary Artery Disease.
Jiang J, Hiron TK, Agbaedeng TA, Malhotra Y, Drydale E, Bancroft J, Ng E, Reschen ME, Davison LJ, O'Callaghan CA.
Circ Res 2024 135 (1) 6-25 PMID:38747151 Pubmed link

Dietary salt intake in chronic kidney disease: recent studies and their practical implications.
O'Callaghan CA.
Pol Arch Intern Med 2024 134 (5) PMID:38546269 Pubmed link

DNA methylases for site-selective inhibition of type IIS restriction enzyme activity.
Flores-Fernández CN, Lin D, Robins K, O'Callaghan CA.
Appl Microbiol Biotechnol 2024 108 (1) 174 PMID:38270650 Pubmed link

Evaluation of a Simple Low-cost Intervention to Empower People with CKD to Reduce Their Dietary Salt Intake: OxCKD1, a Multicenter Randomized Controlled Trial.
O'Callaghan CA, Camidge C, Thomas R, Reschen ME, Maycock AJ, Lasserson DS, Fox RA, Thomas NPB, Shine B, James T.
Kidney360 2023 4 (7) 890-898 PMID:37254243 Pubmed link

Quality of life in older adults with chronic kidney disease and transient changes in renal function: Findings from the Oxford Renal cohort.
Busa I, Ordóñez-Mena JM, Yang Y, Wolstenholme J, Petrou S, Taylor CJ, O'Callaghan CA, Fraser SDS, Taal MW, McManus RJ, Hirst JA, Hobbs FDR.
PLoS One 2022 17 (10) e0275572 PMID:36240168 Pubmed link

Statistical models for the deterioration of kidney function in a primary care population: A retrospective database analysis.
Oke JL, Feakins BG, Schlackow I, Mihaylova B, Simons C, O'Callaghan CA, Lasserson DS, Hobbs FDR, Stevens RJ, Perera R.
F1000Res 2019 8 () 1618 PMID:36225973 Pubmed link

Change in glomerular filtration rate over time in the Oxford Renal Cohort Study: observational study.
Hirst JA, Taal MW, Fraser SD, Mena JMO, O'Callaghan CA, McManus RJ, Taylor CJ, Yang Y, Ogburn E, Hobbs FR.
Br J Gen Pract 2022 72 (717) e261-e268 PMID:34990394 Pubmed link

Impact of the COVID-19 pandemic on emergency department attendances and acute medical admissions.
Reschen ME, Bowen J, Novak A, Giles M, Singh S, Lasserson D, O'Callaghan CA.
BMC Emerg Med 2021 21 (1) 143 PMID:34800973 Pubmed link

Long-term monitoring in primary care for chronic kidney disease and chronic heart failure: a multi-method research programme
Perera R, Stevens R, Aronson JK, Banerjee A, Evans J, Feakins BG, Fleming S, Glasziou P, Heneghan C, Hobbs FDR, Jones L, Kurtinecz M, Lasserson DS, Locock L, McLellan J, Mihaylova B, O’Callaghan CA, Oke JL, Pidduck N, Plüddemann A, Roberts N, Schlackow I, Shine B, Simons CL, Taylor CJ, Taylor KS, Verbakel JY, Bankhead C.
NIHR Journals Library, Southampton (UK) 2021 () PMID:34469090 Pubmed link

Extracellular succinate hyperpolarizes M2 macrophages through SUCNR1/GPR91-mediated Gq signaling.
Trauelsen M, Hiron TK, Lin D, Petersen JE, Breton B, Husted AS, Hjorth SA, Inoue A, Frimurer TM, Bouvier M, O'Callaghan CA, Schwartz TW.
Cell Rep 2021 35 (11) 109246 PMID:34133934 Pubmed link

Frequency of Renal Monitoring - Creatinine and Cystatin C (FORM-2C): an observational cohort study of patients with reduced eGFR in primary care.
Fleming S, Perera-Salazar R, Taylor KS, Jones L, Hobbs FR, James T, O'Callaghan CA, Shine B, Verbakel JY, Stevens R, Bankhead C.
Br J Gen Pract 2021 71 (710) e677-e684 PMID:34048360 Pubmed link

Prevalence and factors associated with multimorbidity among primary care patients with decreased renal function.
Hirst JA, Ordóñez Mena JM, O'Callaghan CA, Ogburn E, Taylor CJ, Yang Y, Hobbs FDR.
PLoS One 2021 16 (1) e0245131 PMID:33449936 Pubmed link

Long-term health outcomes of people with reduced kidney function in the UK: A modelling study using population health data.
Schlackow I, Simons C, Oke J, Feakins B, O'Callaghan CA, Hobbs FDR, Lasserson D, Stevens RJ, Perera R, Mihaylova B.
PLoS Med 2020 17 (12) e1003478 PMID:33326459 Pubmed link

Process of care and activity in a clinically inclusive ambulatory emergency care unit: progressive effect over time on clinical outcomes and acute medical admissions.
Reschen ME, Bowen J, Singh S, Rajwani M, Giles M, Price J, Lasserson D, O'Callaghan CA.
Future Healthc J 2020 7 (3) 234-240 PMID:33094236 Pubmed link

Cytoplasmic Citrate Flux Modulates the Immune Stimulatory NKG2D Ligand MICA in Cancer Cells.
Møller SH, Mellergaard M, Madsen M, Bermejo AV, Jepsen SD, Hansen MH, Høgh RI, Aldana BI, Desler C, Rasmussen LJ, Sustarsic EG, Gerhart-Hines Z, Daskalaki E, Wheelock CE, Hiron TK, Lin D, O'Callaghan CA, Wandall HH, Andresen L, Skov S.
Front Immunol 2020 11 () 1968 PMID:32849657 Pubmed link

Hierarchical Modular DNA Assembly Using MetClo.
Lin D, O'Callaghan CA.
Methods Mol Biol 2020 2205 () 143-159 PMID:32809198 Pubmed link

Prevalence of chronic kidney disease in the community using data from OxRen: a UK population-based cohort study.
Hirst JA, Hill N, O'Callaghan CA, Lasserson D, McManus RJ, Ogburn E, Mena JMO, Shine B, Taylor CJ, Vazquez-Montes MD, Yang Y, Hobbs FR.
Br J Gen Pract 2020 70 (693) e285-e293 PMID:32041766 Pubmed link

Effects of antihypertensives, lipid-modifying drugs, glycaemic control drugs and sodium bicarbonate on the progression of stages 3 and 4 chronic kidney disease in adults: a systematic review and meta-analysis.
Taylor KS, Mclellan J, Verbakel JY, Aronson JK, Lasserson DS, Pidduck N, Roberts N, Fleming S, O'Callaghan CA, Bankhead CR, Banerjee A, Hobbs FR, Perera R.
BMJ Open 2019 9 (9) e030596 PMID:31542753 Pubmed link

Reduced kidney function at presentation in unselected acute emergency medical admissions: incidence, outcome and associated factors.
Yang E, Chalisey A, Reschen ME, Shine B, Lasserson DS, O'Callaghan CA.
Acute Med 2019 18 (3) 158-164 PMID:31536053 Pubmed link

Inosine pranobex enhances human NK cell cytotoxicity by inducing metabolic activation and NKG2D ligand expression.
McCarthy MT, Lin D, Soga T, Adam J, O'Callaghan CA.
Eur J Immunol 2020 50 (1) 130-137 PMID:31434164 Pubmed link

A genetics-led approach defines the drug target landscape of 30 immune-related traits.
Fang H, De Wolf H, Knezevic B, Burnham KL, Osgood J, Sanniti A, Lledó Lara A, Kasela S, De Cesco S, Wegner JK, Handunnetthi L, McCann FE, Chen L, Sekine T, Brennan PE, Marsden BD, Damerell D, O'Callaghan CA, Bountra C, Bowness P, Sundström Y, Milani L, Berg L, Göhlmann HW, Peeters PJ, Fairfax BP, Sundström M, Knight JC.
Nat Genet 2019 51 (7) 1082-1091 PMID:31253980 Pubmed link

Trends in kidney function testing in UK primary care since the introduction of the quality and outcomes framework: a retrospective cohort study using CPRD.
Feakins B, Oke J, McFadden E, Aronson J, Lasserson D, O'Callaghan C, Taylor C, Hill N, Stevens R, Perera R.
BMJ Open 2019 9 (6) e028062 PMID:31196901 Pubmed link

A retrospective analysis of outcomes in low- and intermediate-high-risk pulmonary embolism patients managed on an ambulatory medical unit in the UK.
Reschen ME, Raby J, Bowen J, Singh S, Lasserson D, O'Callaghan CA.
ERJ Open Res 2019 5 (2) PMID:30972349 Pubmed link

Author Correction: Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding.
Walters LC, Harlos K, Brackenridge S, Rozbesky D, Barrett JR, Jain V, Walter TS, O'Callaghan CA, Borrow P, Toebes M, Hansen SG, Sacha JB, Abdulhaqq S, Greene JM, Früh K, Marshall E, Picker LJ, Jones EY, McMichael AJ, Gillespie GM.
Nat Commun 2018 9 (1) 4833 PMID:30420666 Pubmed link

Spanish adaptation of the free OxMaR software for minimization and randomization of clinical studies.
Guillaumes S, O'Callaghan CA.
Gac Sanit 2019 33 (4) 395-397 PMID:30390995 Pubmed link

Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding.
Walters LC, Harlos K, Brackenridge S, Rozbesky D, Barrett JR, Jain V, Walter TS, O'Callaghan CA, Borrow P, Toebes M, Hansen SG, Sacha JB, Abdulhaqq S, Greene JM, Früh K, Marshall E, Picker LJ, Jones EY, McMichael AJ, Gillespie GM.
Nat Commun 2018 9 (1) 3137 PMID:30087334 Pubmed link

MetClo: methylase-assisted hierarchical DNA assembly using a single type IIS restriction enzyme.
Lin D, O'Callaghan CA.
Nucleic Acids Res 2018 46 (19) e113 PMID:29986052 Pubmed link

Activation of the Immune-Metabolic Receptor GPR84 Enhances Inflammation and Phagocytosis in Macrophages.
Recio C, Lucy D, Purvis GSD, Iveson P, Zeboudj L, Iqbal AJ, Lin D, O'Callaghan C, Davison L, Griesbach E, Russell AJ, Wynne GM, Dib L, Monaco C, Greaves DR.
Front Immunol 2018 9 () 1419 PMID:29973940 Pubmed link

Intragenic transcriptional interference regulates the human immune ligand MICA.
Lin D, Hiron TK, O'Callaghan CA.
EMBO J 2018 37 (10) PMID:29643123 Pubmed link

Purine nucleotide metabolism regulates expression of the human immune ligand MICA.
McCarthy MT, Moncayo G, Hiron TK, Jakobsen NA, Valli A, Soga T, Adam J, O'Callaghan CA.
J Biol Chem 2018 293 (11) 3913-3924 PMID:29279329 Pubmed link

The Role of Metabolite-Sensing G Protein-Coupled Receptors in Inflammation and Metabolic Disease.
Recio C, Lucy D, Iveson P, Iqbal AJ, Valaris S, Wynne G, Russell AJ, Choudhury RP, O'Callaghan C, Monaco C, Greaves DR.
Antioxid Redox Signal 2018 29 (3) 237-256 PMID:29117706 Pubmed link

Mouse podoplanin supports adhesion and aggregation of platelets under arterial shear: A novel mechanism of haemostasis.
Lombard SE, Pollitt AY, Hughes CE, Di Y, Mckinnon T, O'callaghan CA, Watson SP.
Platelets 2018 29 (7) 716-722 PMID:29090616 Pubmed link

Systematic Review and Metaanalysis Comparing the Bias and Accuracy of the Modification of Diet in Renal Disease and Chronic Kidney Disease Epidemiology Collaboration Equations in Community-Based Populations.
McFadden EC, Hirst JA, Verbakel JY, McLellan JH, Hobbs FDR, Stevens RJ, O'Callaghan CA, Lasserson DS.
Clin Chem 2018 64 (3) 475-485 PMID:29046330 Pubmed link

Requirement for cystatin C testing in chronic kidney disease: a retrospective population-based study.
Lasserson DS, Shine B, O'Callaghan CA, James T.
Br J Gen Pract 2017 67 (663) e732-e735 PMID:28893765 Pubmed link

The Canine POMC Gene, Obesity in Labrador Retrievers and Susceptibility to Diabetes Mellitus.
Davison LJ, Holder A, Catchpole B, O'Callaghan CA.
J Vet Intern Med 2017 31 (2) 343-348 PMID:28176381 Pubmed link

MICA Expression Is Regulated by Cell Adhesion and Contact in a FAK/Src-Dependent Manner.
Moncayo G, Lin D, McCarthy MT, Watson AA, O'Callaghan CA.
Front Immunol 2016 7 () 687 PMID:28154561 Pubmed link

Global Prevalence of Chronic Kidney Disease - A Systematic Review and Meta-Analysis.
Hill NR, Fatoba ST, Oke JL, Hirst JA, O'Callaghan CA, Lasserson DS, Hobbs FD.
PLoS One 2016 11 (7) e0158765 PMID:27383068 Pubmed link

What is the relationship between renal function and visit-to-visit blood pressure variability in primary care? Retrospective cohort study from routinely collected healthcare data.
Lasserson DS, Scherpbier de Haan N, de Grauw W, van der Wel M, Wetzels JF, O'Callaghan CA.
BMJ Open 2016 6 (6) e010702 PMID:27288374 Pubmed link

Genetic and environmental risk factors for atherosclerosis regulate transcription of phosphatase and actin regulating gene PHACTR1.
Reschen ME, Lin D, Chalisey A, Soilleux EJ, O'Callaghan CA.
Atherosclerosis 2016 250 () 95-105 PMID:27187934 Pubmed link

Biology-The Path Ahead.
O'Callaghan CA.
Biology (Basel) 2011 1 (1) 1-4 PMID:26791675 Pubmed link

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci.
Gaulton KJ, Ferreira T, Lee Y, Raimondo A, Mägi R, Reschen ME, Mahajan A, Locke A, Rayner NW, Robertson N, Scott RA, Prokopenko I, Scott LJ, Green T, Sparso T, Thuillier D, Yengo L, Grallert H, Wahl S, Frånberg M, Strawbridge RJ, Kestler H, Chheda H, Eisele L, Gustafsson S, Steinthorsdottir V, Thorleifsson G, Qi L, Karssen LC, van Leeuwen EM, Willems SM, Li M, Chen H, Fuchsberger C, Kwan P, Ma C, Linderman M, Lu Y, Thomsen SK, Rundle JK, Beer NL, van de Bunt M, Chalisey A, Kang HM, Voight BF, Abecasis GR, Almgren P, Baldassarre D, Balkau B, Benediktsson R, Blüher M, Boeing H, Bonnycastle LL, Bottinger EP, Burtt NP, Carey J, Charpentier G, Chines PS, Cornelis MC, Couper DJ, Crenshaw AT, van Dam RM, Doney AS, Dorkhan M, Edkins S, Eriksson JG, Esko T, Eury E, Fadista J, Flannick J, Fontanillas P, Fox C, Franks PW, Gertow K, Gieger C, Gigante B, Gottesman O, Grant GB, Grarup N, Groves CJ, Hassinen M, Have CT, Herder C, Holmen OL, Hreidarsson AB, Humphries SE, Hunter DJ, Jackson AU, Jonsson A, Jørgensen ME, Jørgensen T, Kao WH, Kerrison ND, Kinnunen L, Klopp N, Kong A, Kovacs P, Kraft P, Kravic J, Langford C, Leander K, Liang L, Lichtner P, Lindgren CM, Lindholm E, Linneberg A, Liu CT, Lobbens S, Luan J, Lyssenko V, Männistö S, McLeod O, Meyer J, Mihailov E, Mirza G, Mühleisen TW, Müller-Nurasyid M, Navarro C, Nöthen MM, Oskolkov NN, Owen KR, Palli D, Pechlivanis S, Peltonen L, Perry JR, Platou CG, Roden M, Ruderfer D, Rybin D, van der Schouw YT, Sennblad B, Sigurðsson G, Stančáková A, Steinbach G, Storm P, Strauch K, Stringham HM, Sun Q, Thorand B, Tikkanen E, Tonjes A, Trakalo J, Tremoli E, Tuomi T, Wennauer R, Wiltshire S, Wood AR, Zeggini E, Dunham I, Birney E, Pasquali L, Ferrer J, Loos RJ, Dupuis J, Florez JC, Boerwinkle E, Pankow JS, van Duijn C, Sijbrands E, Meigs JB, Hu FB, Thorsteinsdottir U, Stefansson K, Lakka TA, Rauramaa R, Stumvoll M, Pedersen NL, Lind L, Keinanen-Kiukaanniemi SM, Korpi-Hyövälti E, Saaristo TE, Saltevo J, Kuusisto J, Laakso M, Metspalu A, Erbel R, Jöcke KH, Moebus S, Ripatti S, Salomaa V, Ingelsson E, Boehm BO, Bergman RN, Collins FS, Mohlke KL, Koistinen H, Tuomilehto J, Hveem K, Njølstad I, Deloukas P, Donnelly PJ, Frayling TM, Hattersley AT, de Faire U, Hamsten A, Illig T, Peters A, Cauchi S, Sladek R, Froguel P, Hansen T, Pedersen O, Morris AD, Palmer CN, Kathiresan S, Melander O, Nilsson PM, Groop LC, Barroso I, Langenberg C, Wareham NJ, O'Callaghan CA, Gloyn AL, Altshuler D, Boehnke M, Teslovich TM, McCarthy MI, Morris AP.
Nat Genet 2015 47 (12) 1415-25 PMID:26551672 Pubmed link

Analysis of Ebola Virus Entry Into Macrophages.
Dahlmann F, Biedenkopf N, Babler A, Jahnen-Dechent W, Karsten CB, Gnirß K, Schneider H, Wrensch F, O'Callaghan CA, Bertram S, Herrler G, Becker S, Pöhlmann S, Hofmann-Winkler H.
J Infect Dis 2015 212 Suppl 2 (Suppl 2) S247-57 PMID:25877552 Pubmed link

Activation of glycoprotein VI (GPVI) and C-type lectin-like receptor-2 (CLEC-2) underlies platelet activation by diesel exhaust particles and other charged/hydrophobic ligands.
Alshehri OM, Montague S, Watson S, Carter P, Sarker N, Manne BK, Miller JL, Herr AB, Pollitt AY, O'Callaghan CA, Kunapuli S, Arman M, Hughes CE, Watson SP.
Biochem J 2015 468 (3) 459-73 PMID:25849538 Pubmed link

Lipid-induced epigenomic changes in human macrophages identify a coronary artery disease-associated variant that regulates PPAP2B Expression through Altered C/EBP-beta binding.
Reschen ME, Gaulton KJ, Lin D, Soilleux EJ, Morris AJ, Smyth SS, O'Callaghan CA.
PLoS Genet 2015 11 (4) e1005061 PMID:25835000 Pubmed link

OxMaR: open source free software for online minimization and randomization for clinical trials.
O'Callaghan CA.
PLoS One 2014 9 (10) e110761 PMID:25353169 Pubmed link

PeaKDEck: a kernel density estimator-based peak calling program for DNaseI-seq data.
McCarthy MT, O'Callaghan CA.
Bioinformatics 2014 30 (9) 1302-4 PMID:24407222 Pubmed link

The Oxford Renal (OxRen) cross-sectional study of chronic kidney disease in the UK.
Hill NR, Lasserson D, Fatoba S, O'Callaghan CA, Pugh C, Perera-Salazar R, Shine B, Thompson B, Wolstenholme J, McManus R, Hobbs FD.
BMJ Open 2013 3 (12) e004265 PMID:24345903 Pubmed link

Solid-phase plate-reader quantification of specific PCR products by measurement of band-specific ethidium bromide fluorescence.
McCarthy MT, O'Callaghan CA.
Anal Biochem 2014 447 () 30-2 PMID:24239570 Pubmed link

Impact on cardiovascular risk follow-up from a shift to the CKD-EPI formula for eGFR reporting: a cross-sectional population-based primary care study.
van Gelder VA, Scherpbier-de Haan ND, de Grauw WJ, O'Callaghan CA, Wetzels JF, Lasserson DS.
BMJ Open 2013 3 (9) e003631 PMID:24071463 Pubmed link

Critical Role for an acidic amino acid region in platelet signaling by the HemITAM (hemi-immunoreceptor tyrosine-based activation motif) containing receptor CLEC-2 (C-type lectin receptor-2).
Hughes CE, Sinha U, Pandey A, Eble JA, O'Callaghan CA, Watson SP.
J Biol Chem 2013 288 (7) 5127-35 PMID:23264619 Pubmed link

Floating-Harbor syndrome and polycystic kidneys associated with SRCAP mutation.
Reschen M, Kini U, Hood RL, Boycott KM, Hurst J, O'Callaghan CA.
Am J Med Genet A 2012 158A (12) 3196-200 PMID:23165645 Pubmed link

Chronic kidney disease: a large-scale population-based study of the effects of introducing the CKD-EPI formula for eGFR reporting.
O'Callaghan CA, Shine B, Lasserson DS.
BMJ Open 2011 1 (2) e000308 PMID:22184586 Pubmed link

NF-κB regulates MICA gene transcription in endothelial cell through a genetically inhibitable control site.
Lin D, Lavender H, Soilleux EJ, O'Callaghan CA.
J Biol Chem 2012 287 (6) 4299-310 PMID:22170063 Pubmed link

Molecular analysis of the interaction of the snake venom rhodocytin with the platelet receptor CLEC-2.
Watson AA, O'Callaghan CA.
Toxins (Basel) 2011 3 (8) 991-1003 PMID:22069753 Pubmed link

Antigen-specific T cell responses to BK polyomavirus antigens identify functional anti-viral immunity and may help to guide immunosuppression following renal transplantation.
Chakera A, Bennett S, Lawrence S, Morteau O, Mason PD, O'Callaghan CA, Cornall RJ.
Clin Exp Immunol 2011 165 (3) 401-9 PMID:21671906 Pubmed link

Expression, purification and crystallization of the human UL16-binding protein ULBP1.
Watson AA, Christou CM, O'Callaghan CA.
Protein Expr Purif 2011 79 (1) 44-8 PMID:21575723 Pubmed link

Structural flexibility of the macrophage dengue virus receptor CLEC5A: implications for ligand binding and signaling.
Watson AA, Lebedev AA, Hall BA, Fenton-May AE, Vagin AA, Dejnirattisai W, Felce J, Mongkolsapaya J, Palma AS, Liu Y, Feizi T, Screaton GR, Murshudov GN, O'Callaghan CA.
J Biol Chem 2011 286 (27) 24208-18 PMID:21566123 Pubmed link

Recognition and blocking of innate immunity cells by Candida albicans chitin.
Mora-Montes HM, Netea MG, Ferwerda G, Lenardon MD, Brown GD, Mistry AR, Kullberg BJ, O'Callaghan CA, Sheth CC, Odds FC, Brown AJ, Munro CA, Gow NA.
Infect Immun 2011 79 (5) 1961-70 PMID:21357722 Pubmed link

A lucky fall? Case report.
Chakera A, Leslie T, Roberts I, O'Callaghan CA, Cranston D.
Transplant Proc 2010 42 (9) 3883-6 PMID:21094877 Pubmed link

Renal transplant immunosuppression impairs natural killer cell function in vitro and in vivo.
Morteau O, Blundell S, Chakera A, Bennett S, Christou CM, Mason PD, Cornall RJ, O'Callaghan CA.
PLoS One 2010 5 (10) e13294 PMID:20967261 Pubmed link

Single nucleotide polymorphism analysis of the NKG2D ligand cluster on the long arm of chromosome 6: Extensive polymorphisms and evidence of diversity between human populations.
Antoun A, Jobson S, Cook M, O'Callaghan CA, Moss P, Briggs DC.
Hum Immunol 2010 71 (6) 610-20 PMID:20219610 Pubmed link

Reversible renal impairment caused by thyroid disease.
Chakera A, Paul HJ, O'Callaghan CA.
Scand J Urol Nephrol 2010 44 (3) 190-2 PMID:20199343 Pubmed link

CLEC-2 activates Syk through dimerization.
Hughes CE, Pollitt AY, Mori J, Eble JA, Tomlinson MG, Hartwig JH, O'Callaghan CA, Fütterer K, Watson SP.
Blood 2010 115 (14) 2947-55 PMID:20154219 Pubmed link

Crystallization and X-ray diffraction analysis of human CLEC5A (MDL-1), a dengue virus receptor.
Watson AA, O'Callaghan CA.
Acta Crystallogr Sect F Struct Biol Cryst Commun 2010 66 (Pt 1) 29-31 PMID:20057064 Pubmed link

The hyponatraemic hairdresser: highlighting the differentials.
Herrington WG, Al-Mossawi MH, Roberts IS, O'Callaghan CA.
Lancet 2009 374 (9698) 1392 PMID:19837256 Pubmed link

The platelet receptor CLEC-2 is active as a dimer.
Watson AA, Christou CM, James JR, Fenton-May AE, Moncayo GE, Mistry AR, Davis SJ, Gilbert RJ, Chakera A, O'Callaghan CA.
Biochemistry 2009 48 (46) 10988-96 PMID:19824697 Pubmed link

Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP.
Bishop B, Aricescu AR, Harlos K, O'Callaghan CA, Jones EY, Siebold C.
Nat Struct Mol Biol 2009 16 (7) 698-703 PMID:19561611 Pubmed link

Chronic kidney disease--assessing the impact.
O'Callaghan CA.
QJM 2009 102 (6) 431-3 PMID:19376794 Pubmed link

Thrombomodulation via CLEC-2 targeting.
O'Callaghan CA.
Curr Opin Pharmacol 2009 9 (2) 90-5 PMID:19091630 Pubmed link

Kidney transplantation--the long term view.
O'Callaghan CA.
QJM 2008 101 (12) 985-6 PMID:18952631 Pubmed link

Crystal structure of rhodocytin, a ligand for the platelet-activating receptor CLEC-2.
Watson AA, Eble JA, O'Callaghan CA.
Protein Sci 2008 17 (9) 1611-6 PMID:18583525 Pubmed link

Renal cells activate the platelet receptor CLEC-2 through podoplanin.
Christou CM, Pearce AC, Watson AA, Mistry AR, Pollitt AY, Fenton-May AE, Johnson LA, Jackson DG, Watson SP, O'Callaghan CA.
Biochem J 2008 411 (1) 133-40 PMID:18215137 Pubmed link

Regulation of ligands for the activating receptor NKG2D.
Mistry AR, O'Callaghan CA.
Immunology 2007 121 (4) 439-47 PMID:17614877 Pubmed link

Structure of the fungal beta-glucan-binding immune receptor dectin-1: implications for function.
Brown J, O'Callaghan CA, Marshall AS, Gilbert RJ, Siebold C, Gordon S, Brown GD, Jones EY.
Protein Sci 2007 16 (6) 1042-52 PMID:17473009 Pubmed link

The crystal structure and mutational binding analysis of the extracellular domain of the platelet-activating receptor CLEC-2.
Watson AA, Brown J, Harlos K, Eble JA, Walter TS, O'Callaghan CA.
J Biol Chem 2007 282 (5) 3165-72 PMID:17132623 Pubmed link

The structure of the human allo-ligand HLA-B*3501 in complex with a cytochrome p450 peptide: steric hindrance influences TCR allo-recognition.
Hourigan CS, Harkiolaki M, Peterson NA, Bell JI, Jones EY, O'Callaghan CA.
Eur J Immunol 2006 36 (12) 3288-93 PMID:17109469 Pubmed link

Defining the T cell antigen proteome of wasp venom.
Aslam A, Kessler B, Batycka M, O'Callaghan CA, Misbah SA, Warrell DA, Ogg G.
Clin Exp Allergy 2006 36 (10) 1274-80 PMID:17014436 Pubmed link

Renal manifestations of systemic autoimmune disease: diagnosis and therapy.
O'Callaghan CA.
Nephrol Ther 2006 2 (3) 140-51 PMID:16890139 Pubmed link

Crystallization and X-ray diffraction analysis of human CLEC-2.
Watson AA, O'Callaghan CA.
Acta Crystallogr Sect F Struct Biol Cryst Commun 2005 61 (Pt 12) 1094-6 PMID:16511244 Pubmed link

Renal manifestations of systemic autoimmune disease: diagnosis and therapy.
O'Callaghan CA.
Best Pract Res Clin Rheumatol 2004 18 (3) 411-27 PMID:15158748 Pubmed link

Structural and energetic aspects of multispecific immune recognition by NKG2D.
O'Callaghan CA, Jones EY.
Structure 2003 11 (4) 360-1 PMID:12679010 Pubmed link

Tetrameric complexes of HLA-E, HLA-F, and HLA-G.
Allan DS, Lepin EJ, Braud VM, O'Callaghan CA, McMichael AJ.
J Immunol Methods 2002 268 (1) 43-50 PMID:12213342 Pubmed link

Characteristics and outcome of membranous nephropathy in older patients.
O'Callaghan CA, Hicks J, Doll H, Sacks SH, Cameron JS.
Int Urol Nephrol 2002 33 (1) 157-65 PMID:12090324 Pubmed link

Direct visualisation of cytomegalovirus-specific CD8+ T cells in renal transplant recipients.
Hilton RM, Hargreaves RE, Sacks SH, O'Callaghan CA.
Transplant Proc 2002 34 (4) 1171-3 PMID:12072306 Pubmed link

Cutting edge: the minor histocompatibility antigen H60 peptide interacts with both H-2Kb and NKG2D.
Cerwenka A, O'Callaghan CA, Hamerman JA, Yadav R, Ajayi W, Roopenian DC, Joyce S, Lanier LL.
J Immunol 2002 168 (7) 3131-4 PMID:11907062 Pubmed link

Molecular competition for NKG2D: H60 and RAE1 compete unequally for NKG2D with dominance of H60.
O'Callaghan CA, Cerwenka A, Willcox BE, Lanier LL, Bjorkman PJ.
Immunity 2001 15 (2) 201-11 PMID:11520456 Pubmed link

Functional characterization of HLA-F and binding of HLA-F tetramers to ILT2 and ILT4 receptors.
Lepin EJ, Bastin JM, Allan DS, Roncador G, Braud VM, Mason DY, van der Merwe PA, McMichael AJ, Bell JI, Powis SH, O'Callaghan CA.
Eur J Immunol 2000 30 (12) 3552-61 PMID:11169396 Pubmed link

Functionally inert HIV-specific cytotoxic T lymphocytes do not play a major role in chronically infected adults and children.
Goulder PJ, Tang Y, Brander C, Betts MR, Altfeld M, Annamalai K, Trocha A, He S, Rosenberg ES, Ogg G, O'Callaghan CA, Kalams SA, McKinney RE Jr, Mayer K, Koup RA, Pelton SI, Burchett SK, McIntosh K, Walker BD.
J Exp Med 2000 192 (12) 1819-32 PMID:11120778 Pubmed link

Recombinant modified vaccinia virus Ankara efficiently restimulates human cytotoxic T lymphocytes in vitro.
Dorrell L, O'Callaghan CA, Britton W, Hambleton S, McMichael A, Smith GL, Rowland-Jones S, Blanchard TJ.
Vaccine 2000 19 (2-3) 327-36 PMID:10930688 Pubmed link

Molecular basis of human natural killer cell recognition of HLA-E (human leucocyte antigen-E) and its relevance to clearance of pathogen-infected and tumour cells.
O'Callaghan CA.
Clin Sci (Lond) 2000 99 (1) 9-17 PMID:10887053 Pubmed link

Differential narrow focusing of immunodominant human immunodeficiency virus gag-specific cytotoxic T-lymphocyte responses in infected African and caucasoid adults and children.
Goulder PJ, Brander C, Annamalai K, Mngqundaniso N, Govender U, Tang Y, He S, Hartman KE, O'Callaghan CA, Ogg GS, Altfeld MA, Rosenberg ES, Cao H, Kalams SA, Hammond M, Bunce M, Pelton SI, Burchett SA, McIntosh K, Coovadia HM, Walker BD.
J Virol 2000 74 (12) 5679-90 PMID:10823876 Pubmed link

Natural killer cell surveillance of intracellular antigen processing pathways mediated by recognition of HLA-E and Qa-1b by CD94/NKG2 receptors.
O'Callaghan CA.
Microbes Infect 2000 2 (4) 371-80 PMID:10817639 Pubmed link

Classical and nonclassical class I major histocompatibility complex molecules exhibit subtle conformational differences that affect binding to CD8alphaalpha.
Gao GF, Willcox BE, Wyer JR, Boulter JM, O'Callaghan CA, Maenaka K, Stuart DI, Jones EY, Van Der Merwe PA, Bell JI, Jakobsen BK.
J Biol Chem 2000 275 (20) 15232-8 PMID:10809759 Pubmed link

Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8+ and CD4+ T lymphocytes.
Oxenius A, Price DA, Easterbrook PJ, O'Callaghan CA, Kelleher AD, Whelan JA, Sontag G, Sewell AK, Phillips RE.
Proc Natl Acad Sci U S A 2000 97 (7) 3382-7 PMID:10737796 Pubmed link

Production of soluble alphabeta T-cell receptor heterodimers suitable for biophysical analysis of ligand binding.
Willcox BE, Gao GF, Wyer JR, O'Callaghan CA, Boulter JM, Jones EY, van der Merwe PA, Bell JI, Jakobsen BK.
Protein Sci 1999 8 (11) 2418-23 PMID:10595544 Pubmed link

Cytotoxic T lymphocytes and viral evolution in primary HIV-1 infection.
Price DA, O'callaghan CA, Whelan JA, Easterbrook PJ, Phillips RE.
Clin Sci (Lond) 1999 97 (6) 707-18 PMID:10585898 Pubmed link

Changes in frequency of HIV-1-specific cytotoxic T cell precursors and circulating effectors after combination antiretroviral therapy in children.
Spiegel HM, DeFalcon E, Ogg GS, Larsson M, Beadle TJ, Tao P, McMichael AJ, Bhardwaj N, O'Callaghan C, Cox WI, Krasinski K, Pollack H, Borkowsky W, Nixon DF.
J Infect Dis 1999 180 (2) 359-68 PMID:10395850 Pubmed link

Cutting edge: HLA-B27 can form a novel beta 2-microglobulin-free heavy chain homodimer structure.
Allen RL, O'Callaghan CA, McMichael AJ, Bowness P.
J Immunol 1999 162 (9) 5045-8 PMID:10227970 Pubmed link

A re-evaluation of the frequency of CD8+ T cells specific for EBV in healthy virus carriers.
Tan LC, Gudgeon N, Annels NE, Hansasuta P, O'Callaghan CA, Rowland-Jones S, McMichael AJ, Rickinson AB, Callan MF.
J Immunol 1999 162 (3) 1827-35 PMID:9973448 Pubmed link

BirA enzyme: production and application in the study of membrane receptor-ligand interactions by site-specific biotinylation.
O'callaghan CA, Byford MF, Wyer JR, Willcox BE, Jakobsen BK, McMichael AJ, Bell JI.
Anal Biochem 1999 266 (1) 9-15 PMID:9887208 Pubmed link

Kupffer cell staining by an HFE-specific monoclonal antibody: implications for hereditary haemochromatosis.
Bastin JM, Jones M, O'Callaghan CA, Schimanski L, Mason DY, Townsend AR.
Br J Haematol 1998 103 (4) 931-41 PMID:9886303 Pubmed link

Oligoclonal expansions of CD8(+) T cells in chronic HIV infection are antigen specific.
Wilson JD, Ogg GS, Allen RL, Goulder PJ, Kelleher A, Sewell AK, O'Callaghan CA, Rowland-Jones SL, Callan MF, McMichael AJ.
J Exp Med 1998 188 (4) 785-90 PMID:9705961 Pubmed link

Structure and function of the human MHC class Ib molecules HLA-E, HLA-F and HLA-G.
O'Callaghan CA, Bell JI.
Immunol Rev 1998 163 () 129-38 PMID:9700506 Pubmed link

Structural features impose tight peptide binding specificity in the nonclassical MHC molecule HLA-E.
O'Callaghan CA, Tormo J, Willcox BE, Braud VM, Jakobsen BK, Stuart DI, McMichael AJ, Bell JI, Jones EY.
Mol Cell 1998 1 (4) 531-41 PMID:9660937 Pubmed link

Production, crystallization, and preliminary X-ray analysis of the human MHC class Ib molecule HLA-E.
O'Callaghan CA, Tormo J, Willcox BE, Blundell CD, Jakobsen BK, Stuart DI, McMichael AJ, Bell JI, Jones EY.
Protein Sci 1998 7 (5) 1264-6 PMID:9605335 Pubmed link

Assembly and crystallization of the complex between the human T cell coreceptor CD8alpha homodimer and HLA-A2.
Gao GF, Gerth UC, Wyer JR, Willcox BE, O'Callaghan CA, Zhang Z, Jones EY, Bell JI, Jakobsen BK.
Protein Sci 1998 7 (5) 1245-9 PMID:9605330 Pubmed link

Direct visualization of antigen-specific CD8+ T cells during the primary immune response to Epstein-Barr virus In vivo.
Callan MF, Tan L, Annels N, Ogg GS, Wilson JD, O'Callaghan CA, Steven N, McMichael AJ, Rickinson AB.
J Exp Med 1998 187 (9) 1395-402 PMID:9565632 Pubmed link

A new look at T cells.
McMichael AJ, O'Callaghan CA.
J Exp Med 1998 187 (9) 1367-71 PMID:9565629 Pubmed link

Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules.
Colonna M, Samaridis J, Cella M, Angman L, Allen RL, O'Callaghan CA, Dunbar R, Ogg GS, Cerundolo V, Rolink A.
J Immunol 1998 160 (7) 3096-100 PMID:9531263 Pubmed link

HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C.
Braud VM, Allan DS, O'Callaghan CA, Söderström K, D'Andrea A, Ogg GS, Lazetic S, Young NT, Bell JI, Phillips JH, Lanier LL, McMichael AJ.
Nature 1998 391 (6669) 795-9 PMID:9486650 Pubmed link

Combined structural and immunological refinement of HIV-1 HLA-B8-restricted cytotoxic T lymphocyte epitopes.
Goulder PJ, Reid SW, Price DA, O'Callaghan CA, McMichael AJ, Phillips RE, Jones EY.
Eur J Immunol 1997 27 (6) 1515-21 PMID:9209505 Pubmed link

Engagement of a T cell receptor by major histocompatibility complex irrespective of peptide.
Vessey SJ, Barouch DH, McAdam SN, Tussey LG, Davenport MA, O'Callaghan CA, Bell JI, McMichael AJ, Jakobsen BK.
Eur J Immunol 1997 27 (4) 879-85 PMID:9130639 Pubmed link

Antagonist HIV-1 Gag peptides induce structural changes in HLA B8.
Reid SW, McAdam S, Smith KJ, Klenerman P, O'Callaghan CA, Harlos K, Jakobsen BK, McMichael AJ, Bell JI, Stuart DI, Jones EY.
J Exp Med 1996 184 (6) 2279-86 PMID:8976183 Pubmed link

Production and crystallization of MHC class I B allele single peptide complexes.
Reid SW, Smith KJ, Jakobsen BK, O'Callaghan CA, Reyburn H, Harlos K, Stuart DI, McMichael AJ, Bell JI, Jones EY.
FEBS Lett 1996 383 (1-2) 119-23 PMID:8612777 Pubmed link

Early prediction of treatment outcome in idiopathic membranous nephropathy.
O'Callaghan CA, Cameron JS, Sacks SH.
QJM 1995 88 (12) 889-94 PMID:8593548 Pubmed link

NSAIDS in the postoperative period. Many factors threaten renal function.
O'Callaghan CA, Andrews PA, Ogg CS.
BMJ 1993 307 (6898) 257 PMID:8369696 Pubmed link

Renal disease and use of topical non-steroidal anti-inflammatory drugs.
O'Callaghan CA, Andrews PA, Ogg CS.
BMJ 1994 308 (6921) 110-1 PMID:8298379 Pubmed link

Acute renal failure associated with NSAIDS.
O'Callaghan CA.
BMJ 1994 308 (6932) 857-8 PMID:8167507 Pubmed link

Prolonged QT syndrome presenting as epilepsy.
O'Callaghan CA, Trump D.
Lancet 1993 341 (8847) 759-60 PMID:8095657 Pubmed link

Prevention of nosocomial respiratory syncytial virus infection.
O'Callaghan CA.
Lancet 1993 341 (8838) 182, author reply 183 PMID:8093788 Pubmed link

Acute arsenic poisoning: absence of polyneuropathy after treatment with 2,3-dimercaptopropanesulphonate (DMPS).
Moore DF, O'Callaghan CA, Berlyne G, Ogg CS, Davies HA, House IM, Henry JA.
J Neurol Neurosurg Psychiatry 1994 57 (9) 1133-5 PMID:8089687 Pubmed link

Effective use of cyclosporin in sarcoidosis: a treatment strategy based on computed tomography scanning.
O'Callaghan CA, Wells AU, Lalvani A, Dhillon PD, Hansell DM, Mitchell DN.
Eur Respir J 1994 7 (12) 2255-6 PMID:7713214 Pubmed link

Handwashing and cohorting in prevention of hospital acquired infections with respiratory syncytial virus.
Isaacs D, Dickson H, O'Callaghan C, Sheaves R, Winter A, Moxon ER.
Arch Dis Child 1991 66 (2) 227-31 PMID:2001109 Pubmed link

Books

Medicine for Finals and Beyond
Editors: Axford JS and O'Callaghan CA
Abingdon : CRC Press, Taylor and Francis Group
First Edition 2023 Library Hub record ; WorldCat record

The Renal system at a Glance
O'Callaghan CA
Fourth Edition 2017. Oxford: Wiley-Blackwell UK.
Library Hub record ; WorldCat record
(Foreign translations include Chinese, Japanese, Spanish, Greek, Russian and Indonesian)

The Renal system at a Glance
O'Callaghan CA
Third Edition 2009. Oxford: Wiley-Blackwell UK.
Library Hub record ; WorldCat record

The Renal system at a Glance
O'Callaghan CA
Second Edition (of The Kidney at a Glance) 2006. Oxford: Wiley-Blackwell UK.
Library Hub record ; WorldCat record

The Kidney system at a Glance
O'Callaghan CA and Brenner BM
First Edition 2000 Oxford: Blackwells Science UK and Boston, USA.
Library Hub record ; WorldCat record

The Oxford Dictionary of Biomedicine
Editor: Lackie J; Advisory Editor: O'Callaghan CA
Oxford University Press, 2010
Library Hub record ; WorldCat record

Medicine. Second Edition
Editors: Axford J and O'Callaghan CA
Oxford : Blackwell Publications 2004
Library Hub record ; WorldCat record

The MRCP part 1:a system based tutorial.
O'Callaghan CA
First Edition. 1997. Oxford:Blackwells Science UK.
Library Hub record ; WorldCat record

Book Chapters

Renal Medicine
Chakera A, Herrington W and O'Callaghan CA
Renal chapters in 'Oxford Diagnosis and Treatment in Internal Medicine'
Editors: Davey P and Sprigings D,
Oxford University Press, 2018

Renal Function
O'Callaghan CA
Chapter 9.1 pp 1027-1039 in 'The Oxford Textbook of Urological Surgery', Editor: F. Hamdy
Oxford University Press 2018

Structure of Nonclassical MHC I (HLA-E, HLA-F, HLA-G, and Orthologs
O'Callaghan CA
Chapter in 'Encyclopedia of Immunobiology', Editor: M.J.H. Ratcliffe
Academic Press, Elsevier, Oxford 2016

Royal College of Physicians MRCP Medical Masterclass: Nephrology
Fluck N, Kalra P, Maxwell P, O'Callaghan CA (ed. Maxwell P)
First edition 2001 Royal College of Physicians Press and Blackwells Science
Second edition 2008

Hypertension and Nephrology
Hill P and O'Callaghan CA
Chapter in 'An Insider's Guide to the Medical Specialties.' Editors: Reckless I and Reynolds J,
Oxford University Press 2006